Women with epilepsy need choice, not diktats, when it comes to sodium valproate

The BLUPs Are Not “Best” When It Comes To Bootstrapping

In the setting of mixed models, some researchers may construct a semiparametric bootstrap by sampling from the best linear unbiased predictor residuals. This paper demonstrates both mathematically and by simulation that such a bootstrap will consistently underestimate the variation in the data in 3nite samples. c © 2002 Published by Elsevier Science B.V.

The dilemma of treating young women with generalized epilepsy with sodium valproate and how to get out of it

Despite the introduction of modern antiepileptic drugs (AEDs) such as lamotrigine or topiramate, sodium valproate (VPA) is seen by many as the most effective medication for seizure control in idiopathic generalized epilepsy (IGE). The case vignettes and the great review by Mole et al. in this issue dramatically illustrate the ill effects of withholding VPA for seizure control and the therapeuti...

Withholding the choice of sodium valproate to young women with generalised epilepsy: Are we causing more harm than good?

PURPOSE Although sodium valproate (VPA) remains the most effective antiepileptic for generalised and unclassified epilepsies, clinicians may be failing to discuss this treatment option because of guideline misinterpretation. Current guidelines recommend caution regarding teratogenic risks but do not advocate absolute avoidance. METHOD We assessed VPA prescribing in young people attending a tr...

Sodium Valproate in Childhood Epilepsy

As the brand Epilim, there is a sugar free liquid and oral syrup both containing sodium valproate 200mg in 5ml. It is also available as sodium valproate 100mg crushable tablets, 200mg and 500mg enteric coated tablets and 200mg, 300mg and 500mg modified release tablets. There are also a number of these preparations available as generic formulations both of sodium valproate and valproic acid. It ...

When It Comes to Clethra: Roots Matter